Manifold for Charity

The Long-Term Future Fund aims to improve the long-term trajectory of civilization by making grants that address global catastrophic risks.

The Quantified Uncertainty Research Institute advances forecasting and epistemics to improve the long-term future of humanity.

Accelerating the development of each vaccine by even a couple of days via COVID-19 human challenge trials could save thousands of lives.

Facilitating scientific breakthroughs by empowering the next generation of scientists and building the 21st century institutions of basic science.

Incubate longtermist nonprofits by connecting founders with ideas, funding, and mentorship.

We search for the charities that save or improve lives the most per dollar.

We help protect people from malaria.

Send money directly to people living in poverty.

We provide independent, impartial medical humanitarian assistance to the people who need it most.

The Animal Welfare Fund aims to effectively improve the well-being of nonhuman animals.

We exist to end the abuse of animals raised for food by influencing the policies of the world’s biggest companies, demanding legislation, and empowering others to take action and leave animals off their plates

Align future machine learning systems with human interests.

We want to make life better for wild animals.

The Trevor Project is the world’s largest suicide prevention and crisis intervention organization for LGBTQ (lesbian, gay, bisexual, transgender, queer, and questioning) young people.

We envision a world where no one is deprived of the opportunity to live a healthy life – and reach their true potential.

For over 70 years, we've led the world by making life-changing breakthroughs in cancer research and patient care, providing the most advanced treatments available.

We help everyone share in the sum of all knowledge.

The Patient Philanthropy Project aims to safeguard and benefit the long-term future of humanity

The ACLU works in the courts, legislatures, and communities to defend and preserve the individual rights and liberties guaranteed to all people in this country by the Constitution and laws of the United States.

Feeding everyone no matter what.

The mission: to expose abuses of power and betrayals of the public trust by government, business, and other institutions, using the moral force of investigative journalism to spur reform through the sustained spotlighting of wrongdoing.

Support and fund research on how ideology and government policy contribute to scientific, technological, and social progress.

WWF works to sustain the natural world for the benefit of people and wildlife, collaborating with partners from local to global levels in nearly 100 countries.

We specialise in the prevention, control and treatment of malaria and other communicable diseases.

Cash incentives to boost vaccination rates and save lives.

The Climate Change Fund aims to sustainably reach net-zero emissions globally, while still allowing growth to free millions from energy poverty.

UNICEF USA helps save and protect the world's most vulnerable children.

The Effective Altruism Infrastructure Fund aims to increase the impact of projects that use the principles of effective altruism.

SCI works with governments in sub-Saharan Africa to create or scale up programs that treat schistosomiasis and soil-transmitted helminthiasis ("deworming").

Through the decades, Save the Children has continued to work to save children’s lives, and that’s still what we do today.

Our mission: to protect people’s health from epidemics and disasters and ensure that communities are resilient to major challenges.

The Global Health and Development Fund aims to improve people's lives, typically in the poorest regions of the world where the need for healthcare and economic empowerment is greatest.

WCK is first to the frontlines, providing meals in response to humanitarian, climate, and community crises. We build resilient food systems with locally led solutions.

Rainforest Trust saves endangered wildlife and protects our planet by creating rainforest reserves through partnerships, community engagement and donor support.

Faunalytics conducts research and shares knowledge to help advocates help animals effectively.

Direct Relief is a humanitarian aid organization, active in all 50 states and more than 80 countries, with a mission to improve the health and lives of people affected by poverty or emergencies – without regard to politics, religion, or ability to pay.

A Future Where People and Nature Thrive

The Free Software Foundation (FSF) is a nonprofit with a worldwide mission to promote computer user freedom.

By improving access to vital nutrition, everyone gets an equal chance to grow, thrive, and prosper.

WRI is a global nonprofit organization that works with leaders in government, business and civil society to research, design, and carry out practical solutions that simultaneously improve people’s lives and ensure nature can thrive.

Providing vital support to high-impact charities and charitable projects.